abstract：:Approximately 5% of patients with IgA nephropathy (IgAN) exhibit mild mesangial lesions with acute onset nephrotic syndrome and diffuse foot process effacement representative of minimal change disease (MCD). It is not clear whether these unusual cases of IgAN with MCD (IgAN-MCD) are variant types of IgAN or coincident...

journal_title：Journal of clinical medicine

authors： Cho WH,Park SH,Choi SK,Jung SW,Jeong KH,Kim YG,Moon JY,Lim SJ,Sung JY,Jhee JH,Chin HJ,Choi BS,Lee SH

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:The Dyskinesia Impairment Scale (DIS) is a new assessment scale for dystonia and choreoathetosis in children and youth with dyskinetic cerebral palsy. Today, the Burke-Fahn-Marsden Dystonia Rating Scale (BFM) is mostly used to assess dystonia in children with inherited dystonia. The aim of this study was to ...

journal_title：Journal of clinical medicine

authors： Danielsson A,Vanmechelen I,Lidbeck C,Krumlinde-Sundholm L,Ortibus E,Monbaliu E,Tedroff K

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND AND AIMS:The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney inj...

journal_title：Journal of clinical medicine

authors： Musiał K,Augustynowicz M,Miśkiewicz-Migoń I,Kałwak K,Ussowicz M,Zwolińska D

更新日期：2020-08-11 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is a frequent neurodevelopmental disorder that often persists into adulthood. Methylphenidate (MPH) is the first-line treatment for ADHD; however, despite its wide usage, little is known about its neurometabolic effects. Until now, no randomized and blinded clinical tria...

journal_title：Journal of clinical medicine

authors： Maier S,Tebartz van Elst L,Philipsen A,Lange T,Feige B,Glauche V,Nickel K,Matthies S,Alm B,Sobanski E,Domschke K,Perlov E,Endres D

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Research findings regarding the association between tricyclic antidepressant (TCA) treatment and the risk of fracture are not consistent; we aimed to assess whether people who take TCAs are at an increased fracture risk. METHODS:Relevant studies published through June 2020 were identified through database s...

journal_title：Journal of clinical medicine

authors： Wu Q,Xu Y,Bao Y,Alvarez J,Gonzales ML

更新日期：2020-08-10 00:00:00

abstract：INTRODUCTION:Traumatic cervical artery dissections are associated with high mortality and morbidity in severely injured patients. After finding even higher incidences than reported before, we decided to incorporate a dedicated head-and-neck computed tomography angiogram (CT-A) in our imaging routine for patients who ha...

journal_title：Journal of clinical medicine

authors： Popp D,Thiedemann C,Bäumler W,Ernstberger A,Alt V,Schicho A

更新日期：2020-08-08 00:00:00

abstract：:Work from our laboratory documents pathological events, including myofiber oxidative damage and degeneration, myofibrosis, micro-vessel (diameter = 50-150 μm) remodeling, and collagenous investment of terminal micro-vessels (diameter ≤ 15 µm) in the calf muscle of patients with Peripheral Artery Disease (PAD). In this...

journal_title：Journal of clinical medicine

authors： Mietus CJ,Lackner TJ,Karvelis PS,Willcockson GT,Shields CM,Lambert NG,Koutakis P,Fuglestad MA,Hernandez H,Haynatzki GR,Kim JKS,DeSpiegelaere HK,Pipinos II,Casale GP

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:There is a paucity of head-to-head comparisons of the efficacy and harms of pharmacological treatments for systemic sclerosis-related interstitial lung disease (SSc-ILD). METHODS:We conducted a network meta-analysis (NMA) in order to compare the effects of different treatments with the placebo on change in ...

journal_title：Journal of clinical medicine

authors： Erre GL,Sebastiani M,Fenu MA,Zinellu A,Floris A,Cavagna L,Renzoni E,Manfredi A,Passiu G,Woodman RJ,Mangoni AA

更新日期：2020-08-07 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of several solid and hematological malignancies. ICIs are not only able to produce long and durable responses, but also very well tolerated by patients. There are several approved indications of use of ICIs in treatment of metastatic gastrointestina...

journal_title：Journal of clinical medicine

authors： Mazloom A,Ghalehsari N,Gazivoda V,Nimkar N,Paul S,Gregos P,Rateshwar J,Khan U

更新日期：2020-08-06 00:00:00

abstract：PURPOSE:To investigate the prognostic significance of diabetes mellitus (DM) in patients with high risk acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (pPCI) in the era of potent antithrombotics. METHODS:Data from 1230 ST-segment elevation myocardial infarction (STEMI) patien...

journal_title：Journal of clinical medicine

authors： Simek S,Motovska Z,Hlinomaz O,Kala P,Hromadka M,Knot J,Varvarovsky I,Dusek J,Rokyta R,Tousek F,Svoboda M,Vodzinska A,Mrozek J,Jarkovsky J,On Behalf Of The Prague-Study Group

更新日期：2020-08-06 00:00:00

abstract：:(1) Background: Little is known about the impact of pathophysiological mechanisms that underlie the enhancement of excitotoxicity and the neuronal consequences of status epilepticus (SE), as well as the clinical consequences of secondary brain insults (SBI) in patients with SE on outcome; (2) Methods: Electronic searc...

journal_title：Journal of clinical medicine

authors： Fontaine C,Jacq G,Perier F,Holleville M,Legriel S

更新日期：2020-08-05 00:00:00

abstract：:Healthcare resource utilization peaks throughout the first year following acute myocardial infarction (AMI). Data linking the former and outcomes are sparse. We evaluated the associations between subsequent length of in-hospital stay (SLOS) and primary ambulatory visits (PAV) within the first year after AMI and long-t...

journal_title：Journal of clinical medicine

authors： Plakht Y,Greenberg D,Gilutz H,Arbelle JE,Shiyovich A

更新日期：2020-08-05 00:00:00

abstract：BACKGROUND:Nine percent of all cases of tuberculosis are bone and joint tuberculosis (BJTB). BJTB occurs in two main forms: spinal (STB) and extraspinal (ESTB). The aim of this study was to compare STB with ESTB in terms of diagnosis, treatment and outcomes. METHODS:We collected demographic, clinical, microbiological,...

journal_title：Journal of clinical medicine

authors： Guillouzouic A,Andrejak C,Peuchant O,Hery-Arnaud G,Hamdad F,Lanotte P,Gaborit B,Bernard L,Bémer P

更新日期：2020-08-05 00:00:00

abstract：:The association between tumor-associated macrophages (TAMs) and the expression of immune checkpoint molecules has not been well described in cutaneous melanoma. We evaluated the correlations between the expression of markers of TAMs, cluster of differentiation 163 (CD163), and immune checkpoint molecules, programmed c...

journal_title：Journal of clinical medicine

authors： Kim YJ,Won CH,Lee MW,Choi JH,Chang SE,Lee WJ

更新日期：2020-08-03 00:00:00

abstract：:Computer-aided diagnosis (CAD) and other risk stratification systems may improve ultrasound image interpretation. This prospective study aimed to compare the diagnostic performance of CAD and the European Thyroid Imaging Reporting and Data System (EU-TIRADS) classification applied by physicians with S-Detect 2 softwar...

journal_title：Journal of clinical medicine

authors： Szczepanek-Parulska E,Wolinski K,Dobruch-Sobczak K,Antosik P,Ostalowska A,Krauze A,Migda B,Zylka A,Lange-Ratajczak M,Banasiewicz T,Dedecjus M,Adamczewski Z,Slapa RZ,Mlosek RK,Lewinski A,Ruchala M

更新日期：2020-08-03 00:00:00

abstract：:The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising tool for the assessment of patients with cancer. We determined the presence of cell-free DNA containing the BRAFV600E mutations (cfBRAFV600E) in plasma samples from 57 patients with papillary thyroid cancer (PTC) with somatic...

journal_title：Journal of clinical medicine

authors： Jensen K,Thakur S,Patel A,Mendonca-Torres MC,Costello J,Gomes-Lima CJ,Walter M,Wartofsky L,Burman KD,Bikas A,Ylli D,Vasko VV,Klubo-Gwiezdzinska J

更新日期：2020-08-02 00:00:00

abstract：:This study aimed at evaluating the clinical relevance of glycoprotein profiles during the earliest phases of rheumatoid arthritis (RA) as biomarkers of cardiovascular (CV) risk and treatment response. Then, GlycA and GlycB serum levels were measured using 1H-nuclear magnetic resonance in 82 early RA patients, 14 clini...

journal_title：Journal of clinical medicine

authors： Rodríguez-Carrio J,Alperi-López M,López P,Pérez-Álvarez ÁI,Gil-Serret M,Amigó N,Ulloa C,Benavente L,Ballina-García FJ,Suárez A

更新日期：2020-08-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is a chronic and prevalent disorder, strongly associated with cardiovascular disease (CVD). The apnea-hypopnea index (AHI), or respiratory event index (REI), and the oxygen desaturation index (ODI) are the clinical metrics of sleep apnea in terms of diagnosis and severity. However, AHI, o...

journal_title：Journal of clinical medicine

authors： Frangopoulos F,Nicolaou I,Zannetos S,Economou NT,Adamide T,Trakada G

更新日期：2020-08-01 00:00:00

abstract：:Crohn's disease (CD) is characterized by compromised immune tolerance to the intestinal commensal microbiota, intestinal barrier inflammation, and hyperplasia of creeping fat (CF) and mesenteric adipose tissue (AT), which seems to be directly related to disease activity. Gut microbiota dysbiosis might be a determining...

journal_title：Journal of clinical medicine

authors： Serena C,Queipo-Ortuño M,Millan M,Sanchez-Alcoholado L,Caro A,Espina B,Menacho M,Bautista M,Monfort-Ferré D,Terrón-Puig M,Núñez-Roa C,Maymó-Masip E,Rodriguez MM,Tinahones FJ,Espin E,Martí M,Fernández-Veledo S,Vendrell J

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND AND AIMS:Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected ...

journal_title：Journal of clinical medicine

authors： Park EY,Baek DH,Lee MW,Kim GH,Park DY,Song GA

更新日期：2020-07-31 00:00:00

abstract：:Regional anesthesia (RA) is an anesthetic technique essential for the performance of ambulatory surgery. Failure rates range from 6% to 20%, and the consequences of these failures have been poorly investigated. We determined the incidence and the impact of regional block failure on patient management in the ambulatory...

journal_title：Journal of clinical medicine

authors： Picard L,Belnou P,Debes C,Lapidus N,Sung Tsai E,Gaillard J,Sautet A,Bonnet F,Lescot T,Verdonk F

更新日期：2020-07-31 00:00:00

abstract：:Acute kidney injury and renal failure are common after heart transplantation. We retrospectively reviewed a national cohort and identified 1129 heart transplant patients. Patients receiving renal replacement therapy after heart transplantation were grouped into the dialysis cohort. The long-term survival and risk fact...

journal_title：Journal of clinical medicine

authors： Wang TJ,Lin CH,Wei HJ,Wu MJ

更新日期：2020-07-31 00:00:00

abstract：:Many studies have shown a global efficacy of laparoscopic surgery for patients with endometriosis in reducing painful symptoms and improving quality of life (QoL) in the short and long-term. The aim of this study was to analyze the different trajectories of long-term evolution in QoL and symptoms following surgical tr...

journal_title：Journal of clinical medicine

authors： Comptour A,Lambert C,Chauvet P,Figuier C,Gremeau AS,Canis M,Pereira B,Bourdel N

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Women affected by Dilated Cardiomyopathy (DCM) experience better outcomes compared to men. Whether a more pronounced Left Ventricular Reverse Remodelling (LVRR) might explain this is still unknown. AIM:We investigated the relationship between LVRR and sex and its long-term outcomes. METHODS:A cohort of 605...

journal_title：Journal of clinical medicine

authors： Cannata A,Manca P,Nuzzi V,Gregorio C,Artico J,Gentile P,Pio Loco C,Ramani F,Barbati G,Merlo M,Sinagra G

更新日期：2020-07-29 00:00:00

abstract：:Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients present with systemic inflammation, we studied the prevalence and predictive value of anemia of inflammation (AI) or functional iron deficiency (FID), originating from immune-mediated alterations of iron homeostasis. Within this ...

journal_title：Journal of clinical medicine

authors： Bellmann-Weiler R,Lanser L,Barket R,Rangger L,Schapfl A,Schaber M,Fritsche G,Wöll E,Weiss G

更新日期：2020-07-29 00:00:00

abstract：:Access to in vitro fertilization (IVF) for obese women varies across centers, and the impact of obesity on IVF outcomes is widely discussed. We assessed the impact of obesity and its severity on live birth rate (LBR) after IVF. We included women treated for IVF in our center. Data were prospectively collected in the B...

journal_title：Journal of clinical medicine

authors： Brunet C,Aouinti S,Huguet F,Macioce V,Ranisavljevic N,Gala A,Avignon A,Mura T,Sultan A

更新日期：2020-07-28 00:00:00

abstract：:The endogenous PP2A inhibitor SET Nuclear Proto-Oncogene (SET) has been reported to play oncogenic roles and determines poor outcomes in colorectal cancer (CRC). Our group previously showed that miR-199b is deregulated in metastatic CRC, and reduced the cell viability and enhanced the sensitivity of CRC cells to stand...

journal_title：Journal of clinical medicine

authors： Cristóbal I,Rubio J,Torrejón B,Santos A,Caramés C,Luque M,Sanz-Álvarez M,Alonso R,Zazo S,Madoz-Gúrpide J,Rojo F,García-Foncillas J

更新日期：2020-07-28 00:00:00

abstract：:Osteoarthritis is a highly prevalent and disabling disease, causing a significant individual and socioeconomic burden worldwide. Until now, there has been a dearth of research exploring the impact of osteoarthritis in global Indigenous communities. Osteoarthritis has a similar risk factor profile to many chronic disea...

journal_title：Journal of clinical medicine

authors： O'Brien P,Bunzli S,Lin I,Gunatillake T,Bessarab D,Coffin J,Garvey G,Dowsey M,Choong P

更新日期：2020-07-27 00:00:00

abstract：:Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of noncaseating granulomas that can occur in any organ, most commonly the lungs. Early and accurate diagnosis of sarcoidosis remains challenging because initial presentations may vary, many patients are asymptomatic, and there is no si...

journal_title：Journal of clinical medicine

authors： Polverino F,Balestro E,Spagnolo P

更新日期：2020-07-24 00:00:00

abstract：:Information on Lyme borreliosis (LB) during pregnancy is limited. In the present study, the course and outcome of erythema migrans (EM) in 304 pregnant women, diagnosed in the period 1990-2015, was assessed and compared with that in age-matched non-pregnant women. The frequency of unfavorable outcome of pregnancies wa...

journal_title：Journal of clinical medicine

authors： Maraspin V,Lusa L,Blejec T,Ružić-Sabljić E,Pohar Perme M,Strle F

更新日期：2020-07-24 00:00:00

abstract：BACKGROUND:Profiles of amino acid metabolites (AAMs) have been linked to obesity and energy homeostasis. We investigated whether baseline obesity-related AAMs were associated with weight status in the early postoperative period after sleeve gastrectomy. METHODS:In this prospective, single-arm, longitudinal study, 27 b...

journal_title：Journal of clinical medicine

authors： Kwon Y,Jang M,Lee Y,Ha J,Park S

更新日期：2020-07-23 00:00:00

abstract：:Bifidobacterium longum (B. longum) ES1 is a probiotic strain capable of modulating microbiome composition, anti-inflammatory activity and intestinal barrier function. We investigated the use of B. Longum ES1 in the treatment of patients with diarrhoea-predominant irritable bowel syndrome (IBS-D). Sixteen patients were...

journal_title：Journal of clinical medicine

authors： Caviglia GP,Tucci A,Pellicano R,Fagoonee S,Rosso C,Abate ML,Olivero A,Armandi A,Vanni E,Saracco GM,Bugianesi E,Astegiano M,Ribaldone DG

更新日期：2020-07-23 00:00:00

abstract：:Suprascapular neuropathy is an uncommon but increasingly recognized cause of shoulder pain and dysfunction due to nerve entrapment. The aim of this review is to summarize some important aspects of this shoulder pathology. An extensive research was performed on PubMed and Clinical Key. The goal was to collect all the a...

journal_title：Journal of clinical medicine

authors： Bozzi F,Alabau-Rodriguez S,Barrera-Ochoa S,Ateschrang A,Schreiner AJ,Monllau JC,Perelli S

更新日期：2020-07-22 00:00:00

abstract：:Hyperkalemia may cause life-threatening cardiac and neuromuscular alterations, and it is associated with high mortality rates. Its treatment includes a multifaceted approach, guided by potassium levels and clinical presentation. In general, treatment of hyperkalemia may be directed towards stabilizing cell membrane po...

journal_title：Journal of clinical medicine

authors： Esposito P,Conti NE,Falqui V,Cipriani L,Picciotto D,Costigliolo F,Garibotto G,Saio M,Viazzi F

更新日期：2020-07-22 00:00:00

abstract：:Hypothermic machine perfusion (HMP) has been introduced as an alternative to static cold storage (SCS) in kidney transplantation, but its true benefit in the clinical routine remains incompletely understood. The aim of this study was to assess the effect of HMP vs. SCS in kidney transplantation. All kidney transplants...

journal_title：Journal of clinical medicine

authors： Gasteiger S,Berchtold V,Bösmüller C,Dostal L,Ulmer H,Bogensperger C,Resch T,Rudnicki M,Neuwirt H,Oberhuber R,Cardini B,Scheidl S,Mayer G,Öfner D,Weissenbacher A,Schneeberger S

更新日期：2020-07-21 00:00:00

abstract：:In this study, we explore the diagnostic accuracy of a Radiographic-based Periodontal Bone Loss (R-PBL) method as a screening tool for periodontitis, in the form of radiographic bone loss, under the 2018 case definition in comparison to the 2012 case definition. The analysis was based on 456 patients (253 females and ...

journal_title：Journal of clinical medicine

authors： Machado V,Proença L,Morgado M,Mendes JJ,Botelho J

更新日期：2020-07-21 00:00:00

abstract：:Small-intestinal neuroendocrine tumors (SI-NETs) are the most prevalent small bowel neoplasms with an increasing frequency. In the multimodal management of SI-NETs, surgery plays a key role, either in curative intent, even if R0 resection is feasible in only 20% of patients due to advanced stage at diagnosis, or palli...

journal_title：Journal of clinical medicine

authors： Deguelte S,Perrier M,Hammoutene C,Cadiot G,Kianmanesh R

更新日期：2020-07-21 00:00:00

abstract：:Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most f...

journal_title：Journal of clinical medicine

authors： Parisis D,Chivasso C,Perret J,Soyfoo MS,Delporte C

更新日期：2020-07-20 00:00:00

abstract：:In clinical practice, it is essential to be able to identify hypoactive sexual desire disorder (HSDD), with its different severity levels and assess the influence the subject's relationship has on the issue. In order to do this, questionnaires are needed that comprise appropriate psychometric properties. We analyzed t...

journal_title：Journal of clinical medicine

authors： Cabello-Santamaría F,Cabello-García MA,Aragón-Vela J,Del Río FJ

更新日期：2020-07-20 00:00:00

abstract：:Pharmacogenetic testing (PGT) is increasingly being used as a tool to guide clinical decisions. This article describes the development of an outpatient, pharmacist-led, pharmacogenetics consult clinic within internal medicine, its workflow, and early results, along with successes and challenges. A pharmacogenetics-tra...

journal_title：Journal of clinical medicine

authors： Arwood MJ,Dietrich EA,Duong BQ,Smith DM,Cook K,Elchynski A,Rosenberg EI,Huber KN,Nagoshi YL,Wright A,Budd JT,Holland NP,Maska E,Panna D,Elsey AR,Cavallari LH,Wiisanen K,Johnson JA,Gums JG

更新日期：2020-07-17 00:00:00